Solesio Lab studies the effects of mitochondrial inorganic polyphosphate on different aspects of the physiology of the organelle, including but not limited to bioenergetics and oxidative status, dynamics, mitophagy, and the regulation of the UPRmt. All these aspects are dysfunctional in neurons in different neurodegenerative disorders, such as Alzheimer’s, Parkinson’s and Huntington’s Diseases, as well as in aging.

To answer our research questions, we use cellular pharmacologically-induced models of neurodegeneration and aging, and an integrated approach of cell biology, microscopy, biochemistry, protein biology, and -omics essays.